Organochlorine exposure estimation in the study of cancer etiology

Environ Res. 1994 Apr;65(1):132-44. doi: 10.1006/enrs.1994.1026.


This paper discusses sampling and design considerations relevant to the estimation of exposure to organochlorine compounds in epidemiological studies. We consider exposures measured directly via biomarkers of exposure in the body. It is critical for the design, implementation, and evaluation of studies that epidemiologists and biostatisticians be familiar with methodological issues relevant to the direct measure of exposure. Etiologic, toxicokinetic, quality control and quality assurance, and statistical sampling are discussed. Finally, the limitations of these studies and the need for complete reporting of methods are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calibration
  • Confidence Intervals
  • Environmental Exposure / adverse effects
  • Environmental Exposure / analysis*
  • Environmental Monitoring / methods*
  • Environmental Monitoring / statistics & numerical data
  • Humans
  • Hydrocarbons, Chlorinated*
  • Insecticides / adverse effects
  • Insecticides / analysis*
  • Insecticides / metabolism
  • Neoplasms / chemically induced*
  • Quality Control
  • Reference Standards


  • Hydrocarbons, Chlorinated
  • Insecticides