Participation of nitric oxide in mouse anaphylactic hypotension

Eur J Pharmacol. 1994 Feb 11;252(3):347-50. doi: 10.1016/0014-2999(94)90185-6.


Mouse hen egg-white lysozyme-specific anaphylaxis was estimated by monitoring changes in blood pressure by using a tail-cuff method. Stimulation of histamine H1 receptors of the vascular endothelium was suggested to be critical for mouse anaphylactic hypotension, because pretreatment with diphenhydramine but not with cimetidine completely inhibited the hypotension. Nitric oxide (NO) was indicated to play an important role in mouse anaphylaxis, because NG-nitro-L-arginine methyl ester, a NO synthase inhibitor, significantly blocked the hypotension while a large amount of L-arginine, a precursor of NO synthesis, restored the hypotension.

MeSH terms

  • Anaphylaxis / physiopathology*
  • Animals
  • Arginine / analogs & derivatives
  • Arginine / pharmacology
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Diphenhydramine / pharmacology
  • Female
  • Hypotension / physiopathology*
  • Male
  • Mice
  • Muramidase
  • NG-Nitroarginine Methyl Ester
  • Nitric Oxide / physiology*
  • Receptors, Histamine H1 / drug effects


  • Receptors, Histamine H1
  • Nitric Oxide
  • Diphenhydramine
  • Arginine
  • Muramidase
  • NG-Nitroarginine Methyl Ester