Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus

Gene. 1994 Apr 8;141(1):141-2. doi: 10.1016/0378-1119(94)90144-9.


The complete nucleotide sequences of the Streptomyces rimosus oxytetracycline (oxyTc) polyketide synthase (PKS)-encoding genes (otcY) has been determined, revealing three open reading frames. The deduced amino-acid sequences correspond to the presumed heterodimeric beta-ketoacyl synthase and acyl carrier protein found in other type-II (multicomponent) PKS systems that specify construction of acetate-derived polyketide antibiotics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Genes, Bacterial / genetics*
  • Molecular Sequence Data
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / genetics*
  • Oxytetracycline / biosynthesis*
  • Restriction Mapping
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Streptomyces / enzymology*
  • Streptomyces / genetics


  • Multienzyme Complexes
  • Oxytetracycline

Associated data

  • GENBANK/Z25538