Hemangiopericytoma of the tongue in a 12-year-old child: ultrastructural and cytogenetic observations

Hum Pathol. 1994 Apr;25(4):425-9. doi: 10.1016/0046-8177(94)90155-4.


We report a case of hemangiopericytoma arising from the tongue of a 12-year-old child. Ultrastructurally, tumor cells revealed discontinuous basal lamina, intermediate-type intercellular junctions, subplasmalemmal thickenings, and smooth muscle-type cytoplasmic filaments. In addition, occasional oligocilia and test tube-like inclusions were observed. Karyotypic analysis of the tumor cells revealed two balanced translocations that have not been reported previously in pediatric solid tumors: one involved chromosomes 1 and 3, t(1;3)(p22;q21), and the other involved chromosomes 7 and 12, t(7;12)(p22;q13). This is the first report of cytogenetic aberrations in a pediatric hemangiopericytoma. Correlation with genetic findings in adult hemangiopericytomas suggests that the chromosome 12q13 rearrangement might be of particular importance.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 3
  • Chromosomes, Human, Pair 7
  • Female
  • Hemangiopericytoma / genetics*
  • Hemangiopericytoma / pathology
  • Hemangiopericytoma / ultrastructure*
  • Humans
  • Karyotyping
  • Tongue Neoplasms / genetics*
  • Tongue Neoplasms / pathology
  • Tongue Neoplasms / ultrastructure*
  • Translocation, Genetic*