Nasal continuous positive airway pressure. Improvement in arterial oxygenation in hyaline membrane disease

Biol Neonate. 1976;29(3-4):231-7. doi: 10.1159/000240868.


Continuous positive airway pressure (CPAP) was employed using nasal prongs in 30 neonates with hyaline membrane disease (HMD). There was a significant improvement in mean PaO2 (from 47 to 80 mmHg;p less than 0.001) with no significant change in PaCO2 or pH within a mean 36 min of therapy. Use of the technique allowed reduction of FiO2 to less than 0.60 in less than 20 h in 18 infants. Infants treated within 24 h of birth had significantly greater improvements in PaO2. Complications were infrequent and only 3 of 30 babies developed a pneumothorax while on nasal CPAP. Only 1 of the 23 survivors required mechanical ventilation in addition to nasal CPAP.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Carbon Dioxide / blood
  • Female
  • Humans
  • Hyaline Membrane Disease / therapy*
  • Hydrogen-Ion Concentration
  • Infant, Newborn
  • Male
  • Oxygen / blood*
  • Partial Pressure
  • Positive-Pressure Respiration* / adverse effects
  • Positive-Pressure Respiration* / instrumentation
  • Time Factors


  • Carbon Dioxide
  • Oxygen