Stroke in Fabry's disease

J Neurol. 1994 Jan;241(3):153-6. doi: 10.1007/BF00868342.


This study was performed to characterize the frequency, clinical presentation and etiology of cerebrovascular complications in patients with Fabry's disease. Thirty-three patients (age range 6-64 years) with Fabry's disease were reviewed, eight (24%) of whom suffered cerebrovascular complications. All patients developed ischemic strokes involving small arterial vessels which occurred in equal frequency in carotid and vertebrobasilar distributions. In six of these eight patients, a stroke occurred prior to age 40 years. Stroke frequently complicates Fabry's disease and represents a significant source of morbidity in patients affected with this condition; it usually involves thrombosis of small arteries affected by the disease process.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Brain Ischemia / epidemiology
  • Brain Ischemia / etiology*
  • Child
  • Fabry Disease / complications*
  • Fabry Disease / diagnosis
  • Female
  • Humans
  • Incidence
  • Intracranial Embolism and Thrombosis / etiology
  • Male
  • Middle Aged
  • Recurrence