This paper reviewed the recent advance in the antioxidant therapy for digestive diseases. Many reports have supported that lipid peroxidation mediated by oxygen radicals is implicated in the pathogenesis of gastric mucosal injury, intestinal damage, acute pancreatitis, and liver injury, and several kinds of antioxidant, which are divided into the preventive antioxidant and chain-breaking antioxidant, are effective in the treatment of these diseases. A new therapeutic approach using synthesized antioxidants, such as zinc-carnosine chelate compound and ebselen, has been also proposed in these fields.