This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Email citation

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 1994 Apr 15;37(8):1035-54.

doi: 10.1021/jm00034a001.

Application of the three-dimensional structures of protein target molecules in structure-based drug design

J Greer¹, J W Erickson, J J Baldwin, M D Varney

Affiliations

PMID: 8164249
DOI: 10.1021/jm00034a001

Review

Application of the three-dimensional structures of protein target molecules in structure-based drug design

J Greer et al. J Med Chem. 1994.

. 1994 Apr 15;37(8):1035-54.

doi: 10.1021/jm00034a001.

Authors

J Greer¹, J W Erickson, J J Baldwin, M D Varney

Affiliation

¹ Department of Structural Biology, Abbott Laboratories, Abbott Park, Illinois 60064.

PMID: 8164249
DOI: 10.1021/jm00034a001

No abstract available

PubMed Disclaimer

Similar articles

Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors.
Thaisrivongs S, Tomich PK, Watenpaugh KD, Chong KT, Howe WJ, Yang CP, Strohbach JW, Turner SR, McGrath JP, Bohanon MJ, et al. Thaisrivongs S, et al. J Med Chem. 1994 Sep 30;37(20):3200-4. doi: 10.1021/jm00046a002. J Med Chem. 1994. PMID: 7932546 No abstract available.
Recent developments in structure-based drug design.
Klebe G. Klebe G. J Mol Med (Berl). 2000;78(5):269-81. doi: 10.1007/s001090000084. J Mol Med (Berl). 2000. PMID: 10954199 Review.
Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.
Ghosh AK, Takayama J, Kassekert LA, Ella-Menye JR, Yashchuk S, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H. Ghosh AK, et al. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4903-4909. doi: 10.1016/j.bmcl.2015.05.052. Epub 2015 May 30. Bioorg Med Chem Lett. 2015. PMID: 26096678 Free PMC article.
Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.
Ghosh AK, Thompson WJ, Fitzgerald PM, Culberson JC, Axel MG, McKee SP, Huff JR, Anderson PS. Ghosh AK, et al. J Med Chem. 1994 Aug 5;37(16):2506-8. doi: 10.1021/jm00042a002. J Med Chem. 1994. PMID: 8057296 No abstract available.
Protein structure--based drug design.
Whittle PJ, Blundell TL. Whittle PJ, et al. Annu Rev Biophys Biomol Struct. 1994;23:349-75. doi: 10.1146/annurev.bb.23.060194.002025. Annu Rev Biophys Biomol Struct. 1994. PMID: 7919786 Review.

See all similar articles

Cited by

How Robust Is the Ligand Binding Transition State?
Bose S, Lotz SD, Deb I, Shuck M, Lee KSS, Dickson A. Bose S, et al. J Am Chem Soc. 2023 Nov 22;145(46):25318-25331. doi: 10.1021/jacs.3c08940. Epub 2023 Nov 9. J Am Chem Soc. 2023. PMID: 37943667 Free PMC article.
NN-RNALoc: Neural network-based model for prediction of mRNA sub-cellular localization using distance-based sub-sequence profiles.
Babaiha NS, Aghdam R, Ghiam S, Eslahchi C. Babaiha NS, et al. PLoS One. 2023 Sep 14;18(9):e0258793. doi: 10.1371/journal.pone.0258793. eCollection 2023. PLoS One. 2023. PMID: 37708177 Free PMC article.
Structural analysis of inhibitor binding to human carbonic anhydrase II.
Boriack-Sjodin PA, Zeitlin S, Chen HH, Crenshaw L, Gross S, Dantanarayana A, Delgado P, May JA, Dean T, Christianson DW. Boriack-Sjodin PA, et al. Protein Sci. 1998 Dec;7(12):2483-9. doi: 10.1002/pro.5560071201. Protein Sci. 1998. PMID: 9865942 Free PMC article.
Innovations in Antifungal Drug Discovery among Cell Envelope Synthesis Enzymes through Structural Insights.
Zhou Y, Reynolds TB. Zhou Y, et al. J Fungi (Basel). 2024 Feb 22;10(3):171. doi: 10.3390/jof10030171. J Fungi (Basel). 2024. PMID: 38535180 Free PMC article. Review.
Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase.
Chambers JM, Hill PA, Aaron JA, Han Z, Christianson DW, Kuzma NN, Dmochowski IJ. Chambers JM, et al. J Am Chem Soc. 2009 Jan 21;131(2):563-9. doi: 10.1021/ja806092w. J Am Chem Soc. 2009. PMID: 19140795 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Other Literature Sources
- The Lens - Patent Citations Database
Chemical Information
- BindingDB