Group II phospholipase A2 in synovial fluid and serum in acute arthritis

Scand J Rheumatol. 1994;23(2):68-72. doi: 10.3109/03009749409103030.


Increased catalytic activity of synovial-type (group II) phospholipase A2 (syn-PLA2), has been associated with cartilage erosions in rheumatoid arthritis and osteoarthritis. The catalytic activity of phospholipase A2 and the concentration of syn-PLA2 were measured in a prospective study in synovial fluid (SF) samples from 66 patients with acute knee joint effusion. The median (range) of the concentration of syn-PLA2 in SF was 210 micrograms/l (80-1480 micrograms/l) in culture-positive septic arthritis, 460 micrograms/l (270-1040 micrograms/l) in reactive arthritis, 780 micrograms/l (120-2710 micrograms/l) in osteoarthritis and 230 micrograms/l (80-1400 micrograms/l) in traumatic joint effusions. High concentrations of syn-PLA2 are found also in SF of patients with arthritides not expected to lead to permanent destruction of cartilage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Arthritis / metabolism*
  • Catalysis
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osmolar Concentration
  • Phospholipases A / blood
  • Phospholipases A / metabolism*
  • Phospholipases A2
  • Synovial Fluid / metabolism*


  • Phospholipases A
  • Phospholipases A2