Optimal drug and behavior therapy for treatment-refractory schizophrenic patients

Am J Psychiatry. 1994 May;151(5):756-9. doi: 10.1176/ajp.151.5.756.


Thirteen treatment-refractory schizophrenic patients (10 men and three women) who were receiving more than 50 mg/day of haloperidol and who had been hospitalized for more than 1 year successfully tolerated a mean dose reduction of 63% with consequent improvement in psychopathology and side effects. The addition of intensive behavior therapy to the optimal dose of haloperidol yielded further improvements in functional behavior, such as self-care and social interaction.

MeSH terms

  • Adult
  • Behavior Therapy*
  • Combined Modality Therapy
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Haloperidol / administration & dosage
  • Haloperidol / therapeutic use*
  • Hospitalization
  • Humans
  • Interpersonal Relations
  • Male
  • Schizophrenia / drug therapy
  • Schizophrenia / therapy*
  • Schizophrenic Psychology
  • Self Care


  • Haloperidol