Fetal lamb pulmonary hypoplasia: pulmonary vascular and myocardial abnormalities

Ann Thorac Surg. 1994 Apr;57(4):946-51. doi: 10.1016/0003-4975(94)90211-9.

Abstract

Neonatal pulmonary hypoplasia resulting from a congenital diaphragmatic hernia (CDH) produces hemodynamic changes and morphologic abnormalities of the pulmonary vasculature. To characterize the myocardial and pulmonary vascular status of the fetus with pulmonary hypoplasia, we studied four chronically instrumented, near-term fetal lambs with pulmonary hypoplasia, induced by producing a diaphragmatic hernia. We found an elevation in the pulmonary arterial pressure (control, 43.8 +/- 5.9 mmHg; CDH, 58.8 +/- 9.1 mmHg; p < 0.05), an elevation in the systemic arterial pressure (control, 43.8 +/- 0.48 mmHg; CDH, 58.6 +/- 6.7 mmHg; p < 0.05), and an elevation in the pulmonary vascular resistance (control, 0.47 +/- 0.11; CDH, 3.87 +/- 1.9; p < 0.05). In addition, though the total pulmonary blood flow was reduced (control, 83.5 +/- 32.9 mL/min; CDH, 22.2 +/- 17.6 mL/min; p < 0.05), the blood flow reduction was proportional to the reduction in the lung mass (control, 79.8 +/- 28.1 [in flow per 100-g lung weight]; CDH, 85.4 +/- 71.7). The increase in the pulmonary vascular resistance in relation to the unit lung mass (control, 0.55 +/- 0.33; CDH, 0.99 +/- 0.5) was not as pronounced as its increase in relation to the total pulmonary blood flow.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abnormalities, Multiple / diagnostic imaging
  • Abnormalities, Multiple / etiology
  • Abnormalities, Multiple / pathology
  • Abnormalities, Multiple / physiopathology*
  • Animals
  • Cardiomyopathies / diagnostic imaging
  • Cardiomyopathies / etiology
  • Cardiomyopathies / pathology
  • Cardiomyopathies / physiopathology*
  • Coronary Circulation*
  • Disease Models, Animal
  • Female
  • Fetal Diseases / diagnostic imaging
  • Fetal Diseases / etiology
  • Fetal Diseases / pathology
  • Fetal Diseases / physiopathology*
  • Hemodynamics*
  • Hernia, Diaphragmatic / complications*
  • Hernias, Diaphragmatic, Congenital*
  • Humans
  • Infant, Newborn
  • Lung / abnormalities*
  • Organ Size
  • Persistent Fetal Circulation Syndrome / diagnostic imaging
  • Persistent Fetal Circulation Syndrome / etiology
  • Persistent Fetal Circulation Syndrome / pathology
  • Persistent Fetal Circulation Syndrome / physiopathology*
  • Pregnancy
  • Pulmonary Circulation*
  • Radionuclide Imaging
  • Sheep