Actin-bundling proteins

Curr Opin Cell Biol. 1994 Feb;6(1):105-9. doi: 10.1016/0955-0674(94)90123-6.


Recent studies have greatly expanded our understanding of actin-bundling proteins. A new group of actin-bundling proteins, the fascins, has been recognized. An actin-bundling protein inhibits actin depolymerization even under conditions in which it cannot produce a gel, which suggests that bundling proteins may affect actin filament dynamics. A villin-like protein is present in Dictyostelium, shedding doubt on current ideas on the evolution of villin. Domain mapping continues to be a major thrust of research into most groups of bundling proteins.

Publication types

  • Review

MeSH terms

  • Actinin / physiology*
  • Actins / physiology*
  • Animals
  • Carrier Proteins / physiology*
  • Dictyostelium / metabolism
  • Humans
  • Membrane Glycoproteins / physiology*
  • Microfilament Proteins / physiology*


  • Actins
  • Carrier Proteins
  • Membrane Glycoproteins
  • Microfilament Proteins
  • plastin
  • villin
  • Actinin
  • fascin