Organization and function of the cytoskeleton in polarized epithelial cells: a component of the protein sorting machinery

Curr Opin Cell Biol. 1994 Feb;6(1):16-24. doi: 10.1016/0955-0674(94)90111-2.


Development and maintenance of cell-surface polarity in epithelial cells requires specialized localization of proteins to functionally and structurally distinct plasma membrane domains. The organization of these domains is dependent upon targeted delivery of transport vesicles between different membrane compartments, and upon protein sorting in the membranes of the Golgi complex and cell surface. Increasing evidence has been gathered in recent years that cytoskeletal components facilitate these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actin Cytoskeleton / physiology
  • Actin Cytoskeleton / ultrastructure
  • Animals
  • Cytoskeleton / metabolism
  • Cytoskeleton / physiology*
  • Cytoskeleton / ultrastructure*
  • Epithelium / metabolism
  • Epithelium / physiology*
  • Epithelium / ultrastructure*
  • Humans
  • Microtubules / physiology
  • Microtubules / ultrastructure
  • Models, Biological
  • Protein Processing, Post-Translational*