Actin-dependent motile forces and cell motility

Curr Opin Cell Biol. 1994 Feb;6(1):82-6. doi: 10.1016/0955-0674(94)90120-1.


Force arising from actin polymerization and myosin activity drives a number of different actin-based cell movements. Several new reports support previous data suggesting that actin polymerization drives lamellipodial protrusion and bacterial propulsion, and one report describes a more indirect role for actin assembly in axonal elongation. The major new findings of the past year concerning possible motility roles for myosin describe myosin-driven protrusion of cell margins.

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Actins / physiology*
  • Animals
  • Cell Movement / physiology*
  • Humans
  • Macromolecular Substances
  • Models, Biological
  • Myosins / metabolism
  • Myosins / physiology*


  • Actins
  • Macromolecular Substances
  • Myosins