Functional properties of non-muscle tropomyosin isoforms

Curr Opin Cell Biol. 1994 Feb;6(1):96-104. doi: 10.1016/0955-0674(94)90122-8.


Tropomyosins are a family of actin filament binding proteins. They have been identified in many organisms, including yeast, nematodes, Drosophila, birds and mammals. In metazoans, different forms of tropomyosin are characteristic of specific cell types. Most non-muscle cells, such as fibroblasts, express five to eight isoforms of tropomyosins. The various isoforms exhibit distinct biochemical properties that appear to be required for specific cellular functions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Cell Movement / physiology*
  • Genes
  • Humans
  • Muscles / physiology
  • Organ Specificity
  • Protein Binding
  • Rats
  • Tropomyosin / chemistry
  • Tropomyosin / genetics
  • Tropomyosin / metabolism*


  • Actins
  • Tropomyosin