Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1

Biochim Biophys Acta. 1994 Apr 28;1221(3):353-6. doi: 10.1016/0167-4889(94)90261-5.

Abstract

The mouse IRS-1 gene has been cloned and its structure determined. Mouse IRS-1 differs from rat by the absence of the potential C-terminal nucleotide binding site. Otherwise, the predicted IRS-1 protein is highly conserved between mouse, rat and humans, especially in the possible phosphorylation sites. The highly conserved nature of IRS-1 suggests the importance of these domains in the function of IRS-1 or its association with other proteins.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Humans
  • Insulin Receptor Substrate Proteins
  • Mice
  • Molecular Sequence Data
  • Phosphoproteins / genetics*
  • Phosphoproteins / metabolism
  • Rats

Substances

  • DNA, Complementary
  • IRS1 protein, human
  • Insulin Receptor Substrate Proteins
  • Irs1 protein, mouse
  • Irs1 protein, rat
  • Phosphoproteins

Associated data

  • GENBANK/L24563