Abstract
Psychobiological theories of mood disorders have been concerned mainly with noradrenaline and serotonin. There exists, however, a recent upsurge of interest in dopamine. We have used single photon emission computed tomography and 123I-iodobenzamide, a high-affinity ligand for D2 receptors, to study these receptors in depression. Subjects were 21 (unipolar) depressed inpatients and 11 normal controls. The mean basal ganglia/cerebellum uptake ratio was 1.94 (+/- 0.27) in the depressed patients versus 1.74 (+/- 0.17) in the controls. This difference was statistically significant (Mann-Whitney U test, p = 0.025). These data could indicate an increase of D2 receptor density in depression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Basal Ganglia / diagnostic imaging
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Basal Ganglia / physiopathology
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Benzamides
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Brain / diagnostic imaging*
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Brain / physiopathology
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Cerebellum / diagnostic imaging
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Cerebellum / physiopathology
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Contrast Media
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Depressive Disorder / diagnostic imaging*
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Depressive Disorder / metabolism
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Depressive Disorder / physiopathology
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Dopamine / metabolism
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Dopamine / physiology*
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Female
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Humans
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Male
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Middle Aged
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Pyrrolidines
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Receptors, Dopamine D2 / metabolism*
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Receptors, Dopamine D2 / physiology
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Tomography, Emission-Computed, Single-Photon*
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Up-Regulation
Substances
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Benzamides
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Contrast Media
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Pyrrolidines
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Receptors, Dopamine D2
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3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide
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Dopamine