[The effect of synthetic enkephalin analogs on the vagus regulation of the heart rhythm]

Fiziol Zh Im I M Sechenova. 1993 Oct;79(10):11-6.
[Article in Russian]


I.v. administration of different enkephalin's analogues inhibited the vagal chronotropic effect in anesthetised cats. The effect was due to selective decrease of the tonic component amplitude whereas that of the synchronizing component either remained unchanged or increased. Different mechanisms seem to be responsible for realisation of the tonic and synchronizing vagal cardiac actions.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cats
  • Electric Stimulation / methods
  • Electrophysiology
  • Enkephalins / pharmacology*
  • Heart Rate / drug effects*
  • Heart Rate / physiology
  • Oligopeptides / pharmacology*
  • Opioid Peptides
  • Vagus Nerve / drug effects*
  • Vagus Nerve / physiology


  • Enkephalins
  • Oligopeptides
  • Opioid Peptides
  • dermorphin