Inhibition of Activin Receptor Signaling Promotes Neuralization in Xenopus

Cell. 1994 Apr 22;77(2):273-81. doi: 10.1016/0092-8674(94)90319-0.

Abstract

Expression of a truncated activin type II receptor, which blocks signaling by activin, neuralizes explants of embryonic cells that would otherwise become epidermal cells. This neuralization is direct and does not require the presence of mesoderm. The induced neural tissue expresses general molecular markers of the central nervous system as well as an array of neural markers along the anteroposterior axis. In the context of the whole embryo, expression of this truncated activin receptor diverts prospective ectoderm and endoderm to a neural fate. We propose that inhibition of the activin type II receptor signaling causes the cells of Xenopus embryos to adopt a neural fate. These results, along with previous experiments performed in Drosophila, suggest that the formation of the nervous system in vertebrates and invertebrates occurs by a common strategy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Activin Receptors
  • Activins
  • Animals
  • Base Sequence
  • Blastomeres / physiology
  • Cell Adhesion Molecules, Neuronal / analysis
  • Central Nervous System / chemistry
  • Central Nervous System / embryology*
  • Embryonic Induction*
  • Germ Layers / chemistry
  • Germ Layers / cytology
  • Germ Layers / radiation effects
  • Inhibins / physiology
  • Molecular Sequence Data
  • Protein-Serine-Threonine Kinases / metabolism*
  • RNA, Messenger / analysis
  • Receptors, Growth Factor / metabolism*
  • Signal Transduction / physiology*
  • Tubulin / analysis
  • Ultraviolet Rays
  • Xenopus laevis

Substances

  • Cell Adhesion Molecules, Neuronal
  • RNA, Messenger
  • Receptors, Growth Factor
  • Tubulin
  • Activins
  • Inhibins
  • Protein-Serine-Threonine Kinases
  • Activin Receptors