Direct screening of a mitochondrial DNA deletion valuable for Amerindian evolutionary research

M Santos; R Barrantes

doi:10.1007/BF00201670

Direct screening of a mitochondrial DNA deletion valuable for Amerindian evolutionary research

Hum Genet. 1994 Apr;93(4):435-6. doi: 10.1007/BF00201670.

Authors

M Santos¹, R Barrantes

Affiliation

¹ Sección de Genética Humana, Instituto de Investigaciones en Salud (INISA), Universidad de Costa Rica, San José.

PMID: 8168814
DOI: 10.1007/BF00201670

Abstract

A rapid, simple restriction isotyping method is described for the direct screening of a previously characterized Amerindian mitochondrial DNA (mtDNA) marker consisting of a 6-bp "Huetar" deletion. In a sample of 31 maternally non-related Chibchan Amerindian Bribri from Costa Rica, this deletion was present in 74%, arguing for the usefulness of this private polymorphism for Amerindian taxonomic research.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Biological Evolution
DNA, Mitochondrial / genetics*
Humans
Indians, Central American / genetics*
Molecular Sequence Data
Sequence Deletion*

Substances

DNA, Mitochondrial