A pressure-recording guide wire for measurements of trans-stenotic gradients in arteries. In vitro validation

Invest Radiol. 1994 Feb;29(2):178-83. doi: 10.1097/00004424-199402000-00011.


Rationale and objectives: A 0.018'' guide wire with a pressure sensor near the tip has been developed for measuring arterial trans-stenotic pressure gradients. The pressure-recording properties of this system in vitro are evaluated.

Methods: Static and dynamic tests were performed with five guide wires. Dynamic tests (step response and recordings of phase and frequency response) were performed with a pressure generator connected to a recording system and a spectrum analyzer.

Results: Zero drift at 3 hours ranged from -1.9 to 2.2 mmHg/hour. Sensitivity drift ranged from 0.3% to 2.1%/hour. Hysteresis ranged from 0.2% to 4.3% (mean 2.4%). Bending in arcs of 180 degrees with diameters < 4 cm changed sensitivity and zero pressure recordings in all guide wires. Dynamic recordings showed a slight undershoot and no oscillation.

Conclusion: Static errors exceeded those of external pressure transducers for fluid-filled catheters, indicating suboptimal recordings of absolute pressures. However, the small size, and the good dynamic properties, make this pressure wire a promising device for recording trans-stenotic pressure gradients in arteries.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arteries / pathology*
  • Catheterization / instrumentation*
  • Constriction, Pathologic
  • In Vitro Techniques
  • Models, Structural