Immunotherapy for Stewart-Treves syndrome. Usefulness of intrapleural administration of tumor-infiltrating lymphocytes against massive pleural effusion caused by metastatic angiosarcoma

J Am Acad Dermatol. 1994 May;30(5 Pt 2):899-903.

Abstract

We describe a 56-year-old woman with Stewart-Treves syndrome who had severe dyspnea from a pleural effusion caused by metastatic angiosarcoma in the right lung. Tumor-infiltrating lymphocytes (TIL) in the pleural effusion were cultured and expanded in vitro in the continuous presence of recombinant interleukin 2 with periodic stimulation by CD3 antibody. The expanded TIL were administered intrapleurally seven times at 1- to 4-week intervals in combination with intravenous infusion of recombinant interleukin 2. A panel of T-cell clones was also obtained from TIL. Immunotherapy dramatically improved the patient's dyspnea and pleural effusion. A CD4+ T-cell clone and a CD8+ T-cell clone established from TIL had specific cytotoxicity to the tumor cells.

Publication types

  • Case Reports

MeSH terms

  • Breast Neoplasms / radiotherapy
  • Breast Neoplasms / surgery
  • Combined Modality Therapy
  • Cytotoxicity, Immunologic
  • Female
  • Hemangiosarcoma / secondary*
  • Hemangiosarcoma / therapy*
  • Humans
  • Immunotherapy*
  • Injections
  • Injections, Intravenous
  • Interleukin-2 / administration & dosage
  • Interleukin-2 / therapeutic use*
  • Lung Neoplasms / secondary*
  • Lung Neoplasms / therapy*
  • Lymphedema / therapy*
  • Lymphocytes, Tumor-Infiltrating*
  • Mastectomy, Radical
  • Middle Aged
  • Neoplasms, Second Primary / therapy*
  • Pleura
  • Pleural Effusion, Malignant / pathology
  • Pleural Effusion, Malignant / therapy*
  • Syndrome

Substances

  • Interleukin-2