Anti-inflammatory and wound healing activity of a growth substance in Aloe vera

J Am Podiatr Med Assoc. 1994 Feb;84(2):77-81. doi: 10.7547/87507315-84-2-77.


Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mg/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.

MeSH terms

  • Aloe*
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Croton Oil
  • Growth Substances / pharmacology*
  • Inflammation / chemically induced
  • Inflammation / drug therapy
  • Male
  • Mannosephosphates / pharmacology
  • Mice
  • Mice, Inbred ICR
  • Plant Extracts / pharmacology*
  • Plants, Medicinal*
  • Wound Healing / drug effects*


  • Anti-Inflammatory Agents
  • Growth Substances
  • Mannosephosphates
  • Plant Extracts
  • mannose-6-phosphate
  • Croton Oil