Complement factor H and related proteins: an expanding family of complement-regulatory proteins?

Immunol Today. 1994 Mar;15(3):121-6. doi: 10.1016/0167-5699(94)90155-4.


Recently, several factor-H-related molecules have been identified in humans and mice, initiating new interest in this group of serum proteins. Although no complement-regulatory activity has been demonstrated yet for the human factor-H-related proteins, the immunological and structural similarities to factor H suggest overlapping functions. Here, Peter Zipfel and Christine Skerka review these similarities and suggest a new nomenclature to identify members of the factor-H-related family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blood Proteins / chemistry*
  • Blood Proteins / physiology*
  • Complement Factor H / chemistry*
  • Complement Factor H / physiology*
  • Humans
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid


  • Blood Proteins
  • CFH protein, human
  • Complement Factor H