Mast cells: function and contents

Curr Opin Immunol. 1994 Feb;6(1):91-7. doi: 10.1016/0952-7915(94)90039-6.


Mast cells, when activated, release a spectrum of mediators that initiate and modulate immediate-type hypersensitivity reactions. Recently is has been reported that expression of mast cell neutral proteases, specific markers of mast cells, is regulated by various growth factors. Human mast cells, like those in rodents, are now known to produce cytokines that modulate IgE production and inflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Chymases
  • Cytokines / biosynthesis
  • Humans
  • Mast Cells / enzymology
  • Mast Cells / immunology
  • Mast Cells / physiology*
  • Serine Endopeptidases / physiology


  • Cytokines
  • Serine Endopeptidases
  • Chymases