Drug-induced reinstatement of extinguished self-administration behavior in monkeys

Pharmacol Biochem Behav. 1975 Nov-Dec;3(6):1055-61. doi: 10.1016/0091-3057(75)90016-7.


Responding was established in squirrel monkeys under a modified progressive ratio schedule of IV d-amphetamine or cocaine self-administration. Subsituation of saline for the drug solutions resulted in extinction of the self-administration behavior. IV injections of certain doses of d-amphetamine or cocaine, immediately prior to test sessions in which response-contingent saline infusions were delivered, reinstated the rate and pattern of responding observed during sessions in which drug was self-administered. Presession IV injections of several doses of pentobarbital or chlorpromazine failed to consistently reinstate responding. These results were interpreted in terms of the discriminative control of drug self-administration behavior by the current drug state of the subject.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Chlorpromazine / pharmacology
  • Cocaine / pharmacology*
  • Dextroamphetamine / pharmacology*
  • Extinction, Psychological / drug effects*
  • Haplorhini
  • Male
  • Pentobarbital / pharmacology
  • Reinforcement Schedule
  • Saimiri
  • Time Factors


  • Pentobarbital
  • Cocaine
  • Dextroamphetamine
  • Chlorpromazine