Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors

Curr Opin Neurobiol. 1994 Feb;4(1):78-86. doi: 10.1016/0959-4388(94)90035-3.


Although first characterized by virtue of their ability to stimulate endothelial cell proliferation in vitro and angiogenesis in vivo, the fibroblast growth factors are now also well recognized for their neurotrophic activities. Understanding the physiological significance of these multifunctional, virtually ubiquitous and pluripotential molecules, however, remains enigmatic. Recent advances describing their molecular, biochemical and biological characteristics has led to a better understanding of their role in the central nervous system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Binding, Competitive
  • Central Nervous System / metabolism
  • Fibroblast Growth Factors / metabolism
  • Fibroblast Growth Factors / physiology*
  • Nerve Degeneration
  • Nerve Growth Factors / physiology*
  • Nervous System Diseases / metabolism
  • Receptors, Fibroblast Growth Factor / metabolism
  • Tissue Distribution


  • Nerve Growth Factors
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors