Circulating intact parathyroid hormone levels in acute pancreatitis

Br J Surg. 1994 Mar;81(3):357-60. doi: 10.1002/bjs.1800810311.


Serum levels of parathyroid hormone (PTH), calcium and albumin were measured daily for 5 days in 41 selected patients with moderate to severe acute pancreatitis. The PTH level was measured by means of a two-site immunoradiometric assay specific for the intact polypeptide. A rise in PTH level was observed more commonly in patients with a complicated or fatal outcome than in those with an uncomplicated course (14 of 16 versus six of 25 patients, P < 0.001). Although PTH levels were variable in the presence of hypocalcaemia, raised concentrations were found more frequently in patients with complications (seven of eight versus two of seven without complications, P = 0.035). This study confirms that an appropriate rise in PTH level occurs in response to the hypocalcaemic stimulus in patients with acute pancreatitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Calcium / blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pancreatitis / blood*
  • Parathyroid Hormone / blood*
  • Peptide Fragments / blood
  • Prognosis
  • Serum Albumin / metabolism
  • Time Factors


  • Parathyroid Hormone
  • Peptide Fragments
  • Serum Albumin
  • Calcium