Serologic HLA typing in cryptogenic Lennox-Gastaut syndrome

Epilepsy Res. 1994 Jan;17(1):43-7. doi: 10.1016/0920-1211(94)90078-7.


Serologic HLA typing was performed on 12 patients with cryptogenic Lennox-Gastaut syndrome and compared to a normal control group of 1661 Caucasians. In the Lennox-Gastaut group we found a significant increase in the frequency of DR5 antigen (55%, chi 2 = 5.6), and an indication of a decrease in the frequency of DR4 antigen (0%, chi 2 = 3.0) as compared with controls (20% and 28%, respectively). No significant differences existed in the frequencies of HLA-A, B, and C antigens between the Lennox-Gastaut group and the controls. These findings contribute to the hypothesis that immunogenetic mechanisms may play a role in triggering or maintaining cryptogenic Lennox-Gastaut syndrome.

MeSH terms

  • Child
  • Epilepsy / immunology*
  • HLA Antigens / analysis*
  • HLA-DR4 Antigen / analysis
  • HLA-DR5 Antigen / analysis
  • Histocompatibility Antigens Class II / analysis
  • Humans
  • Syndrome


  • HLA Antigens
  • HLA-DR4 Antigen
  • HLA-DR5 Antigen
  • Histocompatibility Antigens Class II