Tamoxifen treatment in male infertility. I. Effect on spermatozoa

Fertil Steril. 1994 May;61(5):911-4. doi: 10.1016/s0015-0282(16)56705-3.


Objective: To evaluate the effects of tamoxifen treatment on sperm density, motility, vitality, and morphology.

Design: Placebo-controlled, randomized study.

Setting: Outpatient department.

Interventions: Patients were assigned to two comparable groups: group A (n = 122) was treated with 10 mg tamoxifen twice daily for a period of 3 months and group B (n = 117) was given placebo for the same period of time, following a previously randomized design.

Main outcome measures: In every patient sperm density, motility, viability, and morphology were evaluated 3 months after cessation of treatment.

Results: Mean sperm density in group A improved significantly with a more pronounced improvement in severe oligozoospermic men. Sperm density was found significantly improved compared with group B. Dead spermatozoa in group A significantly decreased after tamoxifen treatment and were also found significantly decreased compared with group B.

Conclusion: It is concluded that tamoxifen exerts a beneficial effect on sperm density and number of live spermatozoa but it has no substantial effect in sperm motility and morphology.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Cell Survival / physiology
  • Double-Blind Method
  • Humans
  • Infertility, Male / drug therapy*
  • Male
  • Oligospermia / drug therapy
  • Oligospermia / pathology
  • Sperm Count
  • Sperm Motility / drug effects
  • Sperm Motility / physiology
  • Spleen / cytology
  • Spleen / drug effects*
  • Spleen / physiology
  • Tamoxifen / therapeutic use*


  • Tamoxifen