Inactivation of HIV, HBV, HCV related viruses and other viruses in human plasma derivatives by pasteurisation

Dev Biol Stand. 1993:81:169-76.


Laboratory studies were made to verify the capacity and efficacy of the pasteurisation step (heat treatment at 60 degrees C for 10 hours in stabilized aqueous solution) in inactivating various pathogenic viruses (e.g. HIV, HBV, HCV related viruses, HAV, HSV, poliovirus). These experiments proved that pasteurisation effectively inactivates a broad spectrum of viruses with a range of different physicochemical properties. The results, summarized in inactivation kinetics, demonstrate that complete inactivation of high quantities of both enveloped (e.g. HIV, HCV related viruses) and non-enveloped (e.g. poliovirus) viruses takes place during pasteurisation. In clinical trials on the virus safety of plasma derivatives no case of AIDS, hepatitis B or C occurred. From these data we conclude that heat treatment at 60 degrees C in a stabilized aqueous solution confers a high margin of safety on human plasma protein preparations regarding the transmission of diseases such as AIDS or hepatitis.

Publication types

  • Review

MeSH terms

  • Biological Products*
  • Clinical Trials as Topic
  • Drug Contamination / prevention & control
  • Flaviviridae / physiology
  • HIV / physiology*
  • Hepacivirus / physiology*
  • Hepatitis B virus / physiology*
  • Hot Temperature*
  • Humans
  • Kinetics
  • Picornaviridae / physiology
  • Plasma / microbiology*
  • Prospective Studies
  • Safety
  • Virus Diseases / prevention & control
  • Virus Replication


  • Biological Products