Direct in vivo observation of transventricular absorption in the hydrocephalic dog using magnetic resonance imaging

Invest Radiol. 1994 Mar;29(3):287-93. doi: 10.1097/00004424-199403000-00006.


Rationale and objectives: A model of chronic noncommunicating hydrocephalus in canines was developed, and gadolinium-DTPA (Gd-DTPA)-enhanced magnetic resonance imaging, physiologic and morphologic studies were performed to investigate transventricular absorption of cerebrospinal fluid.

Methods: Chronic hydrocephalus was induced in 12 mongrel dogs by injection of a silastic mixture into the prepontine cisterns. Ventricular pressure was measured during the development of hydrocephalus, and lateral ventriculo-ventricular perfusions with Gd-DTPA were performed under controlled conditions during serial magnetic resonance imaging studies.

Results: Hydrocephalus developed over an average of 129 +/- 24 days after induction, and the intraventricular pressure increased from an initial level of 14 +/- 4 cm H2O to a stabilized plateau of 25 +/- 5 cm H2O. Increased signal intensity in the brain matter, as seen on magnetic resonance images of chronic hydrocephalic dogs perfused with Gd-DTPA in the lateral ventricles, was consistent with the presence of the contrast agent in the periventricular extracellular space. This increased signal intensity was not observed in control animals.

Conclusions: These results provide direct evidence of transventricular absorption in chronic hydrocephalus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Absorption
  • Animals
  • Cerebral Ventricles / pathology
  • Cerebrospinal Fluid / physiology
  • Contrast Media
  • Dogs
  • Gadolinium DTPA
  • Hydrocephalus / cerebrospinal fluid
  • Hydrocephalus / diagnosis*
  • Hydrocephalus / physiopathology
  • Intracranial Pressure
  • Magnetic Resonance Imaging
  • Organometallic Compounds
  • Pentetic Acid / analogs & derivatives


  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium DTPA