Anti-AIDS Agents, 11. Betulinic Acid and Platanic Acid as anti-HIV Principles From Syzigium Claviflorum, and the anti-HIV Activity of Structurally Related Triterpenoids

J Nat Prod. 1994 Feb;57(2):243-7. doi: 10.1021/np50104a008.


Betulinic acid [1] and platanic acid [2], isolated from the leaves of Syzigium claviforum, were found to be inhibitors of HIV replication in H9 lymphocyte cells. Evaluation of anti-HIV activity with eight derivatives of 1 revealed that dihydrobetulinic acid [3] was also a potent inhibitor of HIV replication. The C-3 hydroxy group and C-17 carboxylic acid group, as well as the C-19 substituents, contribute to enhanced anti-HIV activity. The inhibitory activity of these compounds against protein kinase C (PKC) was also examined, since a correlation between anti-HIV and anti-PKC activities has been suggested. However, there was no apparent correlation between anti-HIV activity and the inhibition of PKC among these compounds.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Cells, Cultured
  • HIV-1 / drug effects*
  • HIV-1 / physiology
  • Humans
  • Lymphocytes / microbiology
  • Plants, Medicinal / chemistry*
  • Protein Kinase C / antagonists & inhibitors
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Virus Replication / drug effects


  • Antiviral Agents
  • Triterpenes
  • betulinic acid
  • platanic acid
  • Protein Kinase C