Continuous insulin infusions in neonates: pharmacologic availability of insulin in intravenous solutions

J Pediatr. 1994 May;124(5 Pt 1):818-20. doi: 10.1016/s0022-3476(05)81382-4.


Continuous insulin infusion is sometimes used in very low birth weight infants with glucose intolerance. We studied the availability of insulin to the neonate by means of a laboratory-simulated clinical infusion under both flushed and non-flushed conditions. Although loss of insulin was noted with both solutions (0.5 U/ml), under the nonflushed condition only 55.9% of the prescribed dose for the first 2 hours was delivered before the delivery rate of the flushed system, 71.4%, was approached. These findings have implications for neonatal insulin administration.

MeSH terms

  • Adsorption
  • Humans
  • Hyperglycemia / drug therapy
  • Infant, Newborn
  • Infusions, Intravenous / instrumentation*
  • Infusions, Intravenous / methods
  • Insulin / administration & dosage*
  • Insulin / pharmacokinetics


  • Insulin