Antineoplastic and antiviral activities of podophyllotoxin related lignans

Arch Pharm (Weinheim). 1994 Mar;327(3):175-9. doi: 10.1002/ardp.19943270309.

Abstract

28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while antiviral assays were performed on herpes simplex virus type I infecting fibroblasts of monkey kidney (HSV/CV-1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both groups of assays at concentrations below 1 microM; deoxypodophyllotoxin (1) being the most potent compound in all cases.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemical synthesis*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Cricetinae
  • Drug Screening Assays, Antitumor
  • Haplorhini
  • Humans
  • Mice
  • Podophyllotoxin / analogs & derivatives*
  • Podophyllotoxin / pharmacology*
  • Tumor Cells, Cultured
  • Viruses / drug effects

Substances

  • Antineoplastic Agents, Phytogenic
  • Antiviral Agents
  • Podophyllotoxin