The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins

Cell Growth Differ. 1994 Feb;5(2):213-9.

Abstract

We have characterized a new human gene, named GARP, localized in the 11q14 chromosomal region. GARP comprises two coding exons, is expressed as two major transcripts of 4.4 and 2.8 kilobases, respectively, and encodes a putative transmembrane protein of 662 amino acids, the extracellular portion of which is almost entirely made of leucine-rich repeats. The molecular weight of the protein immunoprecipitated from transfected cells is 80,000. The GARP protein has structural similarities with the human GP Ib alpha and GP V platelet proteins, and with the Chaoptin, Toll, and Connectin adhesion molecules of Drosophila.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Connectin
  • DNA, Complementary / analysis
  • Drosophila / genetics
  • Drosophila Proteins*
  • Exons
  • Gene Library
  • Humans
  • Insect Hormones / chemistry
  • Leucine
  • Membrane Glycoproteins / chemistry
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics*
  • Mice
  • Molecular Sequence Data
  • Multigene Family*
  • Muscle Proteins / chemistry
  • Platelet Membrane Glycoproteins / chemistry
  • Protein Kinases*
  • Receptors, Cell Surface*
  • Repetitive Sequences, Nucleic Acid
  • Restriction Mapping
  • Sequence Homology, Amino Acid
  • Toll-Like Receptors
  • Transcription, Genetic
  • Transfection

Substances

  • Connectin
  • DNA, Complementary
  • Drosophila Proteins
  • Insect Hormones
  • LRRC32 protein, human
  • Lrrc32 protein, mouse
  • Membrane Glycoproteins
  • Membrane Proteins
  • Muscle Proteins
  • Platelet Membrane Glycoproteins
  • Receptors, Cell Surface
  • TTN protein, human
  • Tl protein, Drosophila
  • Toll-Like Receptors
  • chp protein, Drosophila
  • Protein Kinases
  • Leucine

Associated data

  • GENBANK/Z24680