BCL-2 induction is part of the strategy of Epstein-Barr virus

Leuk Lymphoma. 1994 Feb;12(5-6):413-9. doi: 10.3109/10428199409073782.


Epstein Barr virus can infect B lymphocytes and epithelial cells. Epithelial cells present the natural reservoir for the virus in man. In vitro, infected cells harbor the virus predominantly in a latent state with the expression of a set of nuclear (EBNA 1-6) and latent membrane genes (LMP 1-2) and virus-transformed B cells grow as permanently immortalized lymphoblastoid cell lines, that show increased resistance to various growth inhibiting factors. Here we show that the lymphoma-associated oncogene BCL-2 is upregulated by different latent Epstein-Barr virus genes in B lymphocytes as well as keratinocyte cell lines. Thus, the induction of BCL-2 gene expression seems to be part of the survival strategy of the virus independently of the host cell infected.

MeSH terms

  • B-Lymphocytes / metabolism
  • Base Sequence
  • Cell Line
  • Herpesvirus 4, Human / genetics*
  • Humans
  • Keratinocytes / metabolism
  • Molecular Sequence Data
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogenes*
  • Transfection


  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2