Repeated stress causes reversible impairments of spatial memory performance

Brain Res. 1994 Mar 7;639(1):167-70. doi: 10.1016/0006-8993(94)91778-7.


Restraint stress, 6 h/day for 21 days, caused an impairment, during acquisition, of the performance of a spatial memory task, the eight-arm radial maze. The impairment was reversible, temporally limited and blocked by phenytoin, a blocker of excitatory amino acid action, or tianeptine, an antidepressant, which lowers extracellular serotonin. These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antidepressive Agents, Tricyclic / pharmacology
  • Male
  • Memory*
  • Motor Activity / physiology
  • Phenytoin / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Restraint, Physical
  • Spatial Behavior*
  • Stress, Physiological / etiology
  • Stress, Physiological / psychology*
  • Thiazepines / pharmacology
  • Time Factors


  • Antidepressive Agents, Tricyclic
  • Thiazepines
  • tianeptine
  • Phenytoin