Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells

Cell. 1994 May 6;77(3):361-9. doi: 10.1016/0092-8674(94)90151-1.


The retinal bipolar cell receiving glutamate transmission from photoreceptors mediates a key process in segregating visual signals into ON center and OFF center pathways. This transmission involves a G protein-coupled metabotropic glutamate receptor (mGluR). Immunocytochemical and immunoelectron microscopic studies indicate that restricted localization of a specific mGluR subtype, mGluR6, at the postsynaptic site of the rat rod bipolar cell. This specialization is developmentally regulated: mGluR6 is initially distributed in both the soma and dendrites and is finally concentrated on the postsynaptic site. The mGluR6 localization is reversed when photoreceptors degenerate in the mutant rat with retinal dystrophy. Evidence is thus presented indicating specialized, developmentally regulated receptor distribution in the central nervous system and the crucial role of mGluR6 in photoreceptor-bipolar cell synaptic transmission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • CHO Cells
  • Cricetinae
  • Dendrites / chemistry
  • Fluorescent Antibody Technique
  • Microscopy, Immunoelectron
  • Molecular Sequence Data
  • Molecular Weight
  • Peptides / chemical synthesis
  • Peptides / immunology
  • Protein Kinase C / analysis
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Metabotropic Glutamate / analysis*
  • Receptors, Metabotropic Glutamate / chemistry
  • Retina / chemistry
  • Retina / cytology
  • Retina / growth & development*
  • Retinal Degeneration / metabolism
  • Retinal Degeneration / pathology
  • Retinal Rod Photoreceptor Cells / chemistry*
  • Retinal Rod Photoreceptor Cells / cytology
  • Synaptic Membranes / chemistry*
  • Synaptic Membranes / ultrastructure


  • Peptides
  • Receptors, Metabotropic Glutamate
  • Protein Kinase C