Fructosamine in obese normal subjects and type 2 diabetes

Diabet Med. Jan-Feb 1994;11(1):50-6. doi: 10.1111/j.1464-5491.1994.tb00229.x.

Abstract

The effect of various grades of obesity on serum fructosamine concentrations was studied in Type 2 diabetic (n = 105) and non-diabetic (n = 128) subjects. In obese diabetic and non-diabetic subjects (body mass index > or = 30 kg m-2), the concentration of fructosamine was markedly lower than that obtained for lean diabetic and non-diabetic subjects with similar glycaemic control. Stepwise multiple-regression analysis showed that fructosamine was associated with glycaemic control (as indicated by fasting plasma glucose and glycated haemoglobin), fasting triglycerides, and body mass index in both diabetic and non-diabetic subjects. In vitro studies showed marked decreases in both the extent of [14C]-glucose incorporation into plasma proteins and fructosamine production by incubated sera of obese patients whether diabetic or non-diabetic, with obese subjects with body mass index > 40 kg m-2 exhibiting the greatest decrease. In conclusion, serum fructosamine concentrations are shown to decrease in obese diabetic and non-diabetic subjects with body mass index > or = 30 kg m-2 giving rise to the underestimation of glycaemic control as indicated by fructosamine measurement. A change in the glycation reaction itself may be partly responsible for such decrease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Bilirubin / blood
  • Biomarkers / blood
  • Blood Glucose / metabolism
  • Blood Proteins / analysis
  • Body Mass Index
  • Diabetes Mellitus / blood*
  • Diabetes Mellitus, Type 2 / blood*
  • Female
  • Fructosamine
  • Glycated Hemoglobin A / analysis
  • Glycosylation
  • Hexosamines / blood*
  • Humans
  • Male
  • Middle Aged
  • Obesity / blood*
  • Reference Values
  • Triglycerides / blood

Substances

  • Biomarkers
  • Blood Glucose
  • Blood Proteins
  • Glycated Hemoglobin A
  • Hexosamines
  • Triglycerides
  • Fructosamine
  • Bilirubin