Guillain-Barré syndrome associated with IgM anti-GM1 antibody following Campylobacter jejuni enteritis

Eur J Pediatr. 1994 Mar;153(3):181-3. doi: 10.1007/BF01958981.


We report a 4-year-old girl diagnosed as having Guillain-Barré syndrome after infection by Penner serotype 19 of Campylobacter jejuni. The patient had the HLA-B35 antigen. Neurological examination revealed distal-dominant weakness and intact sensation. Serial electrophysiological studies indicated that the predominant process was axonal degeneration involving motor nerves. An enzyme-linked immunosorbent assay revealed the presence of high titres of serum IgM antibodies to gangliosides GM1 and GM2. The IgM auto-antibody titres decreased concurrently with the clinical course of the illness and no switching from IgM to IgG secretion took place.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Anti-Idiotypic*
  • Campylobacter Infections / complications*
  • Campylobacter Infections / physiopathology
  • Campylobacter jejuni*
  • Child, Preschool
  • Electrophysiology
  • Enteritis / complications*
  • Enteritis / physiopathology
  • Female
  • G(M1) Ganglioside / immunology*
  • Humans
  • Immunoglobulin M / immunology*
  • Polyradiculoneuropathy / immunology*
  • Polyradiculoneuropathy / physiopathology


  • Antibodies, Anti-Idiotypic
  • Immunoglobulin M
  • G(M1) Ganglioside