Survival impact of autoantibodies in systemic lupus erythematosus

J Rheumatol. 1994 Feb;21(2):224-8.


Objective: To determine the frequency, the clinical and laboratory associations, and the impact on survival of anti-dsDNA, anti-Sm, anti-nRNP, anti-Ro, and anti-La in patients with systemic lupus erythematosus (SLE).

Methods: The clinical and laboratory features of 94 patients with SLE tested for anti-dsDNA, anti-nRNP, anti-Sm, anti-Ro and anti-La were studied. Survival analyses were performed by the Kaplan Meier method.

Results: Anti-Ro, anti-nRNP and anti-Sm were found with lower frequency in our patients compared to other reports. There was a higher frequency of anti-Sm (19.5 vs 10%, p = 0.0093) and anti-nRNP positivity (29.2 vs 7.5%, p = 0.006) among African American patients compared to Caucasian patients. No clinical or laboratory associations were found with any of the autoantibodies. Patients had a mean followup up 11.8 years. There were no protective or negative effects of the different autoantibodies on the probability of survival of the patients studied.

Conclusion: Our study failed to demonstrate the impact of the autoantibodies studied in the survival of our patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antibodies, Antinuclear / blood
  • Autoantibodies / blood*
  • Autoantigens
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Erythematosus, Systemic / mortality
  • Male
  • Middle Aged
  • Prognosis
  • Ribonucleoproteins, Small Nuclear*
  • Survival Analysis
  • snRNP Core Proteins


  • Antibodies, Antinuclear
  • Autoantibodies
  • Autoantigens
  • Ribonucleoproteins, Small Nuclear
  • SS-A antibodies
  • SS-B antibodies
  • snRNP Core Proteins