The genes for transcription factor nuclear factor I give rise to corresponding splice variants between vertebrate species

J Mol Biol. 1994 May 20;238(5):860-5. doi: 10.1006/jmbi.1994.1343.

Abstract

Nuclear Factor I (NFI) proteins are DNA binding proteins functioning as transcription and replication factors. As part of a study of the diversity of the Nuclear Factor I protein family, we isolated and sequenced seven NFI cDNA clones from a chicken promacrophage library. Five of these clones are derived from the NFI-A gene, the other two from the NFI-C gene. Comparison of the deduced chicken NFI amino acid sequences with mammalian NFI sequences reveals that there are corresponding vertebrate isoforms, indicating a strong conservation of NFI structure during evolution. This finding leads to the prediction that more mammalian isoforms will be discovered corresponding to the chicken NFI variants reported here.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • CCAAT-Enhancer-Binding Proteins*
  • Chickens
  • Cloning, Molecular
  • DNA, Complementary / analysis
  • DNA-Binding Proteins / genetics*
  • Mammals
  • Molecular Sequence Data
  • NFI Transcription Factors
  • Nuclear Proteins
  • RNA Splicing / genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Transcription Factors / genetics*
  • Y-Box-Binding Protein 1

Substances

  • CCAAT-Enhancer-Binding Proteins
  • DNA, Complementary
  • DNA-Binding Proteins
  • NFI Transcription Factors
  • Nuclear Proteins
  • Transcription Factors
  • Y-Box-Binding Protein 1
  • YBX1 protein, human

Associated data

  • GENBANK/X51486
  • GENBANK/X68152
  • GENBANK/X68153
  • GENBANK/X68154
  • GENBANK/X68155
  • GENBANK/X68156
  • GENBANK/X68157
  • GENBANK/X68158