Abstract
Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, poreforming alpha-subunits and a peripheral beta-subunit. We have cloned a beta-subunit (Kv beta 1) that is specifically expressed in the rat nervous system. Association of Kv beta 1 with alpha-subunits confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the Kv beta 1 amino terminus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Brain / metabolism
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Cattle
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Cloning, Molecular
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In Vitro Techniques
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Ion Channel Gating
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Large-Conductance Calcium-Activated Potassium Channel beta Subunits
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Membrane Potentials / physiology
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Molecular Sequence Data
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Oocytes / physiology
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Peptide Fragments
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Potassium Channels / chemistry*
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Potassium Channels / physiology*
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RNA, Messenger / biosynthesis
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Rats
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Sequence Homology, Amino Acid
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Xenopus laevis
Substances
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Kcnab1 protein, rat
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Kcnab3 protein, rat
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Large-Conductance Calcium-Activated Potassium Channel beta Subunits
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Peptide Fragments
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Potassium Channels
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RNA, Messenger
Associated data
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GENBANK/X70662
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GENBANK/X76724