Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit

Nature. 1994 May 26;369(6478):289-94. doi: 10.1038/369289a0.


Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, poreforming alpha-subunits and a peripheral beta-subunit. We have cloned a beta-subunit (Kv beta 1) that is specifically expressed in the rat nervous system. Association of Kv beta 1 with alpha-subunits confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the Kv beta 1 amino terminus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / metabolism
  • Cattle
  • Cloning, Molecular
  • In Vitro Techniques
  • Ion Channel Gating
  • Large-Conductance Calcium-Activated Potassium Channel beta Subunits
  • Membrane Potentials / physiology
  • Molecular Sequence Data
  • Oocytes / physiology
  • Peptide Fragments
  • Potassium Channels / chemistry*
  • Potassium Channels / physiology*
  • RNA, Messenger / biosynthesis
  • Rats
  • Sequence Homology, Amino Acid
  • Xenopus laevis


  • Kcnab1 protein, rat
  • Kcnab3 protein, rat
  • Large-Conductance Calcium-Activated Potassium Channel beta Subunits
  • Peptide Fragments
  • Potassium Channels
  • RNA, Messenger

Associated data

  • GENBANK/X70662
  • GENBANK/X76724