The Unp proto-oncogene encodes a nuclear protein

Oncogene. 1994 Jun;9(6):1729-31.


The mouse Unp gene is related to TRE17, a human oncogene, but is not its mouse homolog. Unp is a ubiquitously expressed gene producing two related mRNAs. The protein product of Unp is localized in the nucleus. Expression of Unp from a highly active promoter results in tumorigenic transformation of NIH3T3 cells injected into athymic mice. Unp therefore encodes a novel nuclear oncoprotein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Amino Acid Sequence
  • Animals
  • Mice
  • Mice, Nude
  • Molecular Sequence Data
  • Nuclear Proteins / genetics*
  • Oncogene Proteins / chemistry
  • Oncogene Proteins / genetics*
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • Proto-Oncogenes*
  • Ubiquitin Thiolesterase
  • Ubiquitin-Specific Proteases


  • MAS1 protein, human
  • Nuclear Proteins
  • Oncogene Proteins
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • Usp4 protein, mouse
  • Ubiquitin Thiolesterase
  • Ubiquitin-Specific Proteases