Intrahepatic biliary strictures after liver transplantation

Radiology. 1994 Jun;191(3):735-40. doi: 10.1148/radiology.191.3.8184054.


Purpose: To evaluate the prevalence, cholangiographic features, causes, and management of intrahepatic biliary strictures in hepatic transplants.

Materials and methods: Over a 12-year period, cholangiography was performed in 1,590 liver allografts. Confirmed cases of stricture were evaluated and correlated with clinical variables.

Results: Intrahepatic biliary strictures occurred in 130 of 1,590 grafts (8.2%). Strictures were multiple in 99 grafts (76.2%) and single in 31 (23.8%). Locations were the common hepatic duct bifurcation in 46 grafts (35.4%), the peripheral ducts in 44 (33.8%), and both in 40 (30.8%). Strictures caused mild to moderate bile duct dilatation in 72 grafts (55.4%), marked dilatation in 11 (8.5%), and obstruction in four (3.1%). Hepatic artery occlusion, pretransplantation primary sclerosing cholangitis, choledochojejunostomy, use of Euro-Collins organ preservation solution, cholangitis at liver biopsy, and young age were statistically significantly associated with strictures (P < .001).

Conclusion: Strictures have multiple causes and may be an important indicator of underlying abnormalities. They often require interventional radiologic or surgical treatment.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bile Ducts, Intrahepatic / diagnostic imaging
  • Bile Ducts, Intrahepatic / pathology*
  • Bile Ducts, Intrahepatic / transplantation
  • Child
  • Child, Preschool
  • Constriction, Pathologic / diagnostic imaging
  • Constriction, Pathologic / etiology
  • Female
  • Humans
  • Infant
  • Liver Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Postoperative Care
  • Radiography
  • Retrospective Studies