Lipocortin-1: cellular mechanisms and clinical relevance

Trends Pharmacol Sci. 1994 Mar;15(3):71-6. doi: 10.1016/0165-6147(94)90281-x.


Lipocortin-1, a 37 kDa member of the annexin superfamily of proteins, originally evoked interest as one of the 'second messengers' of the anti-inflammatory actions of the glucocorticoids. Subsequent research has shown that the protein plays a major regulatory role in systems as diverse as cell-growth regulation and differentiation, neutrophil migration, CNS responses to cytokines, neuroendocrine secretion and neurodegeneration. The role of lipocortin-1 in mediating glucocorticoid-induced effects in these systems has been demonstrated using immunoneutralization strategies and by mimicking steroid actions with highly purified or recombinant lipocortin-1 or its biologically active peptide fragments. Originally the mode of action of lipocortin-1 seemed to be largely through inhibition of prostaglandin formation, but it is now clear that it can modify other aspects of cell function, perhaps pointing to a more fundamental mechanism than was originally envisaged. In this article Rod Flower and Nancy Rothwell review the nature, possible mechanisms and clinical relevance of these diverse actions of lipocortin-1.

Publication types

  • Review

MeSH terms

  • Animals
  • Annexin A1 / biosynthesis
  • Annexin A1 / metabolism
  • Annexin A1 / physiology*
  • Brain / metabolism
  • Cell Differentiation
  • Cell Division
  • Humans
  • Neurosecretory Systems / metabolism
  • Tissue Distribution


  • Annexin A1