Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

Trends Pharmacol Sci. 1994 Mar;15(3):77-83. doi: 10.1016/0165-6147(94)90282-8.


Receptors that are coupled to the production of inositol (1,4,5)-trisphosphate cause an increase in cytosolic free Ca2+ concentration as a consequence of both Ca2+ mobilization from intracellular stores and Ca2+ influx through the plasma membrane. Although this latter phenomenon appears attributable to the activation of a number of Ca(2+)-permeable channels, the channels that are controlled by the Ca2+ content of the intracellular stores have recently received much attention. In this review, Cristina Fasolato, Barbara Innocenti and Tullio Pozzan summarize the characteristics of this Ca(2+)-influx pathway and discuss the hypotheses about its mechanism of activation and its relationship with other receptor-activated Ca2+ channels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / drug effects
  • Calcium Channels / metabolism*
  • Cytosol / metabolism
  • Electrophysiology
  • GTP-Binding Proteins / physiology
  • Humans
  • Second Messenger Systems / physiology*


  • Calcium Channels
  • GTP-Binding Proteins
  • Calcium

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