An RNA-binding Protein Gene, TLS/FUS, Is Fused to ERG in Human Myeloid Leukemia With t(16;21) Chromosomal Translocation

Cancer Res. 1994 Jun 1;54(11):2865-8.

Abstract

The t(16;21)(p11;q22) translocation is a recurrent chromosomal abnormality found in several types of myeloid leukemia. We have previously demonstrated that the breakpoints of this translocation are clustered in a specific intron of the ERG gene on chromosome 21, which has recently been reported to be involved in Ewing's sarcoma. We show here that the TLS/FUS gene on chromosome 16 is fused with the ERG gene to produce the TLS/FUS-ERG chimeric transcript by this translocation. The TLS/FUS gene has been identified as a translocated gene in myxoid liposarcoma by the t(12;16)(q13;p11) translocation and encodes an RNA-binding protein that is highly homologous to the product of the EWS gene involved in Ewing's sarcoma. Thus, the TLS/FUS-ERG gene fusion in t(16;21) leukemia is predicted to produce a protein that is very similar to the EWS-ERG chimeric protein responsible for Ewing's sarcoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosomes, Human, Pair 16*
  • Chromosomes, Human, Pair 21*
  • Humans
  • Leukemia, Myeloid / genetics*
  • Liposarcoma, Myxoid / genetics
  • Molecular Sequence Data
  • Neoplasm Proteins / chemistry
  • Neoplasm Proteins / genetics*
  • Polymerase Chain Reaction
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / genetics*
  • Sarcoma, Ewing / genetics
  • Translocation, Genetic / genetics*

Substances

  • Neoplasm Proteins
  • RNA-Binding Proteins

Associated data

  • GENBANK/S71718
  • GENBANK/S71805