Human glutathione S-transferases

Int J Biochem. 1994 Mar;26(3):295-308. doi: 10.1016/0020-711x(94)90050-7.


1. Multiple forms of glutathione S-transferase (GST) isoenzymes present in human tissues are dimers of subunits belonging to three distinct gene families namely alpha, mu and pi. Only the subunits within each class hybridize to give active dimers. 2. These subunits are differentially expressed in a tissue-specific manner and the composition of glutathione S-transferases in various tissues differs significantly. 3. Minor GST subunits not belonging to these three classes are also present in some tissues. 4. An ortholog of rat GST 8-8 and mouse mGSTA4-4 is selectively expressed in some human tissues including bladder, brain, heart, liver, and pancreas. This isoenzyme designated as GST 5.8 expresses several fold higher activity towards 4-hydroxy-2,3-trans-nonenal as compared to the routinely used substrate 1-chloro-2,4-dinitrobenzene.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Female
  • Glutathione Transferase* / chemistry
  • Glutathione Transferase* / classification
  • Glutathione Transferase* / genetics
  • Glutathione Transferase* / metabolism
  • Humans
  • Isoenzymes
  • Male
  • Sex Characteristics
  • Terminology as Topic
  • Tissue Distribution


  • Isoenzymes
  • Glutathione Transferase